Support Your Overall Health by Enhancing and Feeding Your Gut Bacteria.

You will, stay healthy, have more energy throughout the day and think more clearly when you feed  your gut.

Approximately 70% of our immune system begins in the gut  where a complex microbiome ecosystem is found. It lives primarily on complex carbohydrates called “poly-saccarides”.

Build your healthy gut bacteria with herbs like reishi mushroom. When you support your gut, your mood and your entire immune system work optimally.

(Each 100g packet of Immune Boost is approximately a 30 day supply.)

• Reishi mushroom (Ganoderma) has concentrated polysaccharides, exactly what your gut bacteria eat

• Traditional Asian herbs have been used for centuries to boost health

• No pills – No capsules full of fillers

• Highly concentrated cooked and dried granules of Reishi, Astragalus and others herbs

Papers reviewed:

• 2023 April (Ekiz et al) – Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections
• 2024 Jan (Sijia Wu et al) – Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

2023 April (Ekiz et al) – Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections

• Ganoderma lucidum, a species of mushroom in the Ganoderma genus of the Ganodermataceae family.
• This mushroom is known by different names across various countries and cultures. In Japan, it is referred to as “Reishi”, which means “spiritual potency”. In China, it is known as “Lingzhi”, which means “divine mushroom”, while in Korea, it is called “Youngzhi”, meaning “mushroom of immortality”.
• This multiporous mushroom typically grows on the stumps of various deciduous trees, including oak, maple, elm, willow, sweetgum, magnolia, and acacia. In addition, it also grows in Europe, Asia, and North and South America, especially in temperate regions
• G. lucidum was recorded in the ancient Chinese herbal encyclopedia
• The structure of G. lucidum is generally fan-shaped, kidney-shaped, or semicircular, and it typically exhibits a dark red, reddish-brown, or reddish-black color.
• The Latin root, “Lucidum”, meaning bright, has been linked to the shiny appearance of these mushrooms
• An analysis of G. lucidum extract:
  • 11.1% glucose, 10.2% minerals (including K, Mg, and Ca), and 7.3% protein
  • biologically active components, such as polysaccharides, triterpenes, flavonoids, alkaloids, steroids, unsaturated fatty acids
  • therapeutic properties of G. lucidum have primarily been attributed to its polysaccharides and triterpenoids
• In general, the components of G. lucidum can be listed as follows:
  • 1. Polysaccharides and glycoproteins (α-D-glucans, β-glucans, β-D-glucans, polysaccharide–protein complexes, and α-D-mannans) [5,15,16].
  • 2. Terpenoids (ganoderic acid A–Z, ganoderals, ganosporeric acid A, lucidenic acids, and ganoderiols) [5,15,16].
  • 3. Nitrogenous compounds (aspartic acid, glutamic acid, lysine, leucine, methionine, cysteine, and nucleotides) [16].
  • 4. Other components (phosphorus, germanium, calcium, sulfur, and magnesium)
• Studies have found that G. lucidum contains:
  • more than 200 different types of polysaccharides.
  • 380 types of terpenoids and more than 30 steroidal groups
• bitterness of Ganoderma’s fruiting body is due to its triterpene/triterpenoid secondary metabolites.
• Triterpenes possess various beneficial activities, such as antitumor, anti-inflammatory, antioxidant, antihepatitis, antimalarial, hypoglycemic, antimicrobial, and anti-HIV activities
• polysaccharides found in G. lucidum exhibit several beneficial effects, such as anticancer, antioxidant, antimicrobial, immunomodulatory, hypoglycemic, and anti-inflammatory effects, and also protect the intestinal mucosal barrier
• Ganoderma contains high levels of germanium, which possesses antimutagenic, antitumor, immune-enhancing, and antioxidant properties
• Ganoderma contains bioactive peptides such as lectins, ribonucleases, and laccases
• Ganoderma is a rich source of enzymes, such as superoxide dismutase, lysozyme, and protein enzymes, that are essential for our body’s disease defense and metabolic processes
• Ganoderma’s steroid, ganodosterone, possesses antihepatotoxic activity.
• Furthermore, Ganoderma is a source of vitamins C and E as well as β-carotene

Consumption

• Due to their tough and rigid fruiting bodies, Ganoderma species are not considered suitable for consumption
• Mushrooms are commonly consumed in various forms, such as capsules, liquid extracts, chewable tablets, rice wine, tea, syrup, hair and skin care products, and tea, to obtain their therapeutic benefits.
• G. lucidum, for instance, is dried, powdered, and marketed as a dietary supplement to harness its pharmacological properties.
• global sales of these products are estimated to exceed US$ 2.5 billion annually

Mechanisms of Action:

Antioxidant

• reactive oxygen species (ROS) can adversely affect cells, they have been linked to various ailments, such as cancer, cardiovascular diseases, neurodegenerative diseases, diabetes, inflammatory diseases, immune system disorders, and aging
• Antioxidants function by scavenging free radicals, chelating pro-oxidative metals, extinguishing singlet oxygen and photosensitive substances
• antioxidant properties of G. lucidum have been scientifically established and are attributed to its constituent polysaccharides, glycoproteins, triterpenes, amino acids, and phenolic compounds
• antioxidant effects of triterpenes and leucine amino acids, as well as glycoproteins produced by combining polysaccharides with peptides or proteins through covalent bonds, have also been well established
• G. lucidum phenolic compounds: quercetin, myricetin, gallic acid, chlorogenic acid, protocatechin, cinnamic acid, p-hydroxybenzoic acid, and p-coumaric acid, have exhibited antioxidant activities
• freeze-dried G. lucidum was found to possess superior antioxidant activity in comparison to heat-dried G. lucidum.

Anti-cancer

• G. lucidum-derived polysaccharides and triterpenoids exhibit anticancer activity through various mechanisms
• polysaccharides: stimulate immune system (macrophages, T cells, B cells) to produce cytokines and activate anticancer activities of immune cells
  • also have cytotoxic effect on cancer cells, reduce integrin expression to hinder tumor cell adhesion, promote apoptosis of cancer cells, and impede angiogenesis
• triterpenoids: inhibit metastatic growth of cancerous cells, suppress attack of cancerous cells, cytotoxicity in cancer cells
• Phenolic compounds inhibit the invasion and metastasis of cancer cells

Cardiovascular Diseases

• G. lucidum, which has been used in traditional medicine for many years in the Far East and defined as the mushroom of immortality, has positive effects on cardiovascular diseases
• positive effects of G. lucidum extracts on CVD are based on their effects on blood pressure, lipids, diabetes, and obesity; preventing blood platelets from sticking together; and reducing low-density lipoprotein cholesterol, total cholesterol, and triglycerides due to their antioxidant activities
  • triterpenes – anti-inflammatory by scavenging ROS
  • polysaccharides prevent CVD by protecting endothelial cells in blood vessels, lower blood pressure, improve lipid metabolism

Anti-diabetic

• diabetes, a term first used by the Greek doctor Aretus in the 2nd century, was defined by the WHO in 1999 as a metabolic disorder resulting in disruptions in carbohydrate, fat, and protein metabolism due to insulin secretion or the effects of insulin
• Type 1 is caused by insufficient insulin production due to the destruction of beta cells in the pancreas.
• Type 2 diabetes, on the other hand, begins with insulin resistance, which is the insufficiency of insulin secretion in the body and the inability of cells to respond to insulin correctly
• antidiabetic activities of polysaccharides, triterpenoids, proteins, and glycoproteins extracted from G. lucidum have been proven in studies
• G. lucidum polysaccharides reduce serum glucose, insulin, lipid, triglyceride, and cholesterol levels
• Diabetic rats fed with G.lucidum had significantly reduced fasting blood glucose and insulin levels

COVID-19

• adequate intake of macro- and micronutrients is essential for a strong and healthy immune system.
• Vitamins (such as vitamins A, B, C, D, and E) and minerals, such as iron and zinc, play important roles in immune function
  • Vitamin B, specifically B6 and B12, is important for DNA production and repair and can also help with immune cell function.
  • Vitamin C is a powerful antioxidant that can increase phagocytosis, oxidant production, and neutrophil migration to the site of infection.
  • Vitamin D is important for the responsiveness of T cells, B cells, dendritic cells, and monocytes, which are all involved in immune function.
  • Vitamin E can increase lymphocyte proliferation, immunoglobulin levels, antibody responses, natural killer cell activity, interleukin-2 production, and macrophage activity, all of which can contribute to a stronger immune system.
  • Iron is essential for the production and maturation of immune cells, including lymphocytes. It is also involved in the production of cytokines, which are important for immune function.
  • Zinc is involved in a wide range of immune functions, including the prevention of free radical-induced damage, the activation of macrophages and other immune cells, and the regulation of cytokine levels. Zinc is also important for the growth and differentiation of T and B cells, which are important for adaptive immunity
• G. lucidum polysaccharides stimulate cellular and humoral immune reactions by increasing the production of T cells, cytokines (interleukin-2, interleukin 1β, interferon-y, and tumor necrosis factor-α), monocytes, and macrophages.
  • β-glucans have a mechanism to prevent infections, including COVID-19, due to increased inflammatory responses by upregulating pattern recognition receptors
  • ganoderic acids contribute to antiviral activity of G.lucidum
  • phenolic compounds (luteolin, quercetin) also treat COVID-19
  • the bioactive compounds inhibit viral entry into host cell, and inhibit viral replication.

Challenges

• lack of standardized products.
• There is currently no standardization regarding the type of G. lucidum used, the extraction method, or the composition of the active constituent

2024 Jan (Sijia Wu et al) – Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

• 
• G. lucidum has been used medicinally in China for more than 2000 years.
• its medicinal value was first described in Shen Nong Ben Cao Jing, the earliest pharmacopeia in China, written in the Eastern Han dynasty of China (25-220AD)
• medicinal value of G. lucidum was unknown to Western civilization until the 20^th century
• more than 300 compounds have been isolated from G. lucidum
• Recently, G. lucidum has become one of the most studied and product-developed medicinal fungi

Anti-tumor effect

• Numerous laboratory researchers and preclinical trials have shown that G. lucidum has extensive anticancer activity
• G. lucidum can induce cell-cycle arrest and apoptosis, inhibit angiogenesis, invasion and metastasis, and tumor growth to exert its anticancer activity in vitro and in vivo
• Action shown against ovarian cancer cells, cervical cancer in mice, breast cancer, glioblastoma
• G. lucidum is used as adjuvant therapy with chemotherapy or radiotherapy in cancer treatment to prolong long-term survival, promote life quality, and regulate immunity.

Antiviral activity

• G.lucidum has shown anti-viral activity against EBV, HPV, HIV

Antidiabetes

• Bioactive components isolated from G. lucidum exhibit potent anti-diabetic efficacy – dramatically reduce fasting blood glucose and insulin, correct aberrant lipid metabolism

Renal and Hepatic Protective Effects

• Futrakul et al found that 5 patients with impaired renal function showed significantly decreased proteinuria after taking a crude extract of G. lucidum for 1 year.
• can treat acute liver damage

Neuroprotective Effects

• G. lucidum is neuroprotective in ischemia/reperfusion or traumatic spinal cord injury in experimental models
• weekly seizure frequency was reduced in patients with epilepsy after administering G. lucidum spore powder
• G. lucidum also shows curative effects on depression in combination therapy

Safety, toxicity, and side effects

• G. lucidum includes triterpenes, polysaccharides, nucleosides, steroids, fatty acids, alkaloids, proteins, peptides, amino acids, and inorganic elements.
• Most reports illustrated that one or some of them are not causing apparent toxicity or safety problems.
• Rodent animals, for example, can tolerate up to 5000 mg/kg dose of G. lucidum administration, and no mortality rate was reported
• In healthy human volunteers 1.5 g/day and 4 consecutive weeks of exposure did not affect their hemostatic parameters as well as platelet and global hemostatic functions

What I find fascinating  is Reishi, is the fact that Reishi has hundreds of bioactive compounds with impressive medicinal properties.

For Reishi mushroom, the two classes of bioactive compounds with the most medicinal properties are the polysaccharides and triterpenes, however, it is clear that there are many other beneficial compounds.

Reishi mushroom could help the COVID-19 mRNA Vaccine injured who are suffering from:

1. mRNA Vaccine Damaged immune system (recurrent viral infections)
2. Cardiovascular disease, diabetes, high blood pressure, dyslipidemia
3. Suffered damage to their liver or kidneys
4. Suffered neurological damage or mental health changes
5. Suffering from stress, depression, anxiety, difficulty sleeping
6. Suffered damage to their gut microbiome
7. Chronic fatigue / mitochondrial damage (usually due to reactive oxygen species – Reishi is a powerful antioxidant)

Immune Boost Herb Pack Ingredients

All Products Acne Clear Brain Boost Herb Pack CBD Topical Salve Corydalis Natural Pain Relief Herb Pack Fertility Tea Herb Pack Immune Boost Herb Pack iSleep Herb Pack Libido Boost Herb Pack Her Libido Boost Herb Pack Him Menopause Relief Herb Pack Natural Pet Calm Herb Pack PMS Relief Herb Pack Relax Herb Pack Skinny Boost Herb Pack Sperm Boost Herb Pack Sugar Control Herb Pack

• 
  Astragalus root / MilkvetchAstragalus promotes T-Cells and activates B-Cells. Astragalus contains compounds which slow cell aging and increase DNA repair ability.
• 
  Ginger root (Sheng Jiang)Loaded with nutrients and bioactive compounds ginger provides various effects including anti-inflammatory and the ability to inhibit the growth of many different types of bacteria. Ginger root is commonly used for issues from digestion to inflammation.  
• 
  Jujube fruit (Da Zao)Jujube harmonizes the Spirit, promoting calmness and alleviates anxiety.  This fruit is often used for insomnia, palpitations, and poor memory, supporting overall emotional well-being and vitality.  This natural fruit contains critically important vitamins, minerals, antioxidants, flavonoids(...)
• 
  Licorice Root (Gan Cao)Licorice has a long and highly varied record of uses. It was and remains one of the most important herbs in Traditional Chinese Medicine. It is said this herb goes to all twelve channels of the body, a claim given to only a few Chinese herbs. By entering all body channels this herb is often(...)
• 
  Reishi Mushroom (Ganoderma Lucidum)Reishi mushroom contains large amounts of polysaccharides which are food for our gut bacteria. By feeding your gut bacteria you boost diversity and colonies of beneficial bacteria which in turn boost your immune system.

Usage instructions:

Mix 1/2 tsp. of Immune Boost Herb Pack in hot water and wait 5 minutes,
OR put granules straight into your mouth and swallow with water or juice. Mixing with other drinks or food will inhibit digestion.
Immune Boost Herb Pack is best taken 30 minutes before or after meals to allow for optimum digestion and bio-availability of these herbs. The strength of the herbal formula is maximized when taken apart from other foods and drinks.

• This combination of herbs has an inherited synergy of the herbs working together.

• 10:1 extract (one gram of this product is equivalent to ten grams of dried herbs)

• No unnecessary fillers – NO magnesium stearate.

• Pacific Herbs sells only the highest quality concentrated herbal granules.

• Our commitment: To provide the finest quality botanical supplements.

Standardized quality control testing on each batch of raw herbs and formulas. Each product batch is tracked with lot numbers and expiration dates. Lot numbers correspond to “Certificates Of Analysis” otherwise known as “COA’s”.

Medicinal Mushrooms: Current Use in Clinical Practice   https://www.liebertpub.com/doi/10.1089/act.2020.29275.kha

Astragalus

Astragalus promotes T-Cells and has been shown to activate B-Cells. Astragalus contains compounds which slow cell aging through reduced telomere shortening rate, oxidative stress, and increasing DNA repair ability.
Pubmed Data: DNA Cell Biol. 2010 Jan;29(1):33-9. PMID: 19839736

Astragalus contains two isomers which decrease the expression of p16, which may slow aging. Pubmed Data : Chin Med J (Engl). 2008 Feb 5;121(3):231-5. PMID: 18298915